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Kodi mapiritsi a benoxate ndi mankhwala otani?

Benorilate imadziwikanso kuti paracetamol, antipyretic, ndi benzol. Dzina la mankhwala: 4- (acetamido) phenyl 2- (acetoxy) benzoic acid ester.

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Makhalidwe a mapiritsi a benoxate

Mapiritsi a Benoate ndi lipophilic yomwe imapangidwa ndi aspirin ndi gulu la paracetamol hydroxyl, lomwe limalowetsa m'malo mwa magulu akulu omwe amayambitsa poizoni ndi zoyipa zake m'magulu a-hydroxyl ndi carboxyl, ndikuyika aspirin kuti athetse ululu. , Anti-kutupa kwenikweni ndi mphamvu ya antipyretic ya paracetamol. Zimathetsa zolakwika za aspirin ndi aminopyrine yochepetsera malungo mwadzidzidzi. Imakhala ndi mafuta osungunuka bwino ndipo imasungunuka pang'onopang'ono m'magazi kukhala osiyana kwambiri ndi ma aspirin ndi ma paracetamol monomers. Metabolites, motero zotsatira zake ndizofatsa, zotsatira zake zimakhala zabwino, ndipo kusinthasintha kumakhala kwamphamvu.

1. Kuchita mwachangu, kusungunuka kwabwino komanso kupezeka kwakukulu.

2. Zomwe zimachitika chifukwa chokhwima ndizochepa. Popeza mankhwalawa samadutsa hydrolysis m'matumbo am'mimba, amalimbana ndi mkwiyo wa antipyretic analgesics pamatumbo am'mimba, ndipo samakhala osokoneza bongo ndipo amadalira kugwiritsa ntchito nthawi yayitali.

3. Zilibe mphamvu pakatikati yamanjenje yamthupi nthawi zonse. Ndizabwino kwambiri komanso zotetezeka zikagwiritsidwa ntchito kwa makanda ndi ana aang'ono omwe malo awo owongolera kutentha sanakhwime.

4. Palibe fungo lapadera, lomwe lingatengedwe kapena kutafuna; Kugwiritsa ntchito mankhwala osokoneza bongo kwa nthawi yayitali, osakhudza gawo la magazi, hematopoietic function, chiwindi, ntchito ya impso, chitetezo chamthupi. Chifukwa chake, Nochisha ndi mankhwala abwino kubanja.

Zotsatira zamankhwala zamapiritsi a benoxate

Pambuyo poyamwa mapiritsi a Benoate, imakhala ndi antipyretic effect poletsa cyclooxygenase mkatikati mwa manjenje ndikuchepetsa kaphatikizidwe ka prostaglandin (PG); ili ndi mphamvu yothetsera vuto poletsa PG synthase m'matumba am'mimba; Kudzera mu chopinga cha kaphatikizidwe ka PG pakayankha kotupa, zotsatira zofananira zothandizirazo zimapangidwa. ndiye kuti:

1. Antipyretic effect: imalepheretsa chisangalalo cha kutentha kwa thupi, kuchepetsa kutentha kwa thupi; pangani mitsempha ya khungu kukachuluka, kutuluka thukuta kwambiri, ndikufulumizitsa kutaya kwanyengo (osakhudza kutentha kwa thupi).

2. Mphamvu ya analgesic: kuletsa mapangidwe a antigen-antibody, kulepheretsa kuphatikiza kwa matupi a antigen; chitani mwachindunji pamalo olandirira, pewani kupangika kwa oyimira ululu (PG), ndikukhala ndi zotsatira zotulutsa zinthu zopweteka mukamalimbana ndi kuwonongeka kwa minofu.

3. Zotsutsana ndi zotupa: ziletsa mapangidwe azinthu zamagulu monga prostaglandin, histamine, fetus fetus, ndi zina, ndikutsutsa kukondoweza kwawo; okhazikika lysosomal nembanemba; kuchepetsa kupezeka kwa mitsempha m'matenda otupa, kuchotsa madzi; khalani ndi fibrinolytic Sinthani ma microcirculation.

Zisonyezo za Mapiritsi a Benoate

1. Amagwiritsidwa ntchito pochizira chimfine, malungo, ndi matenda ena, ndipo ali ndi vuto lalikulu la antipyretic.

2. Zotsatira zosiyanasiyana za analgesic. Mankhwala amkati, neurology, obstetrics and gynecology, ENT, ndi ena amagwiritsidwa ntchito pochiza mutu, kupweteka kwa mano, neuralgia, kutupa pakhosi ndi kupweteka, kupweteka kwa minofu, kupweteka msambo, kupweteka kwa pambuyo pa ntchito, kupweteka kwa ululu, ndi zina zambiri, zogwira mtima mkati mwa mphindi 20, Mulingo woyenera udutsa 98%; makamaka kupweteka kosatha.

3. Pochizira matenda a nyamakazi a chifuwa chachikulu, kuchuluka kwake ndi 94.3% yolumikizana ndi mafupa, kupweteka kwa msana, komanso kusagwirizana.

4. Imakhala ndi othandizira othandizira othandizira kupweteketsa mtima komanso kutupa kwazomwe zimayambitsidwa ndi ma virus ndi mabakiteriya ena.

5. Kuphatikiza apo, mankhwalawa amathanso kugwiritsidwa ntchito popewa ndikuchiza matenda am'magazi am'magazi komanso thrombosis. Zili ndi zotsutsana ndi kuphatikizika kwamaplatelet chifukwa cha collagen ndi adenosine diphosphate, ndipo imatha kuchepetsa thrombosis.


Nthawi yamakalata: May-17-2021